Neurotransmitter loading into synaptic vesicle

Across TCGA patient cohorts, RNA activity of the Neurotransmitter loading into synaptic vesicle pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYP-AS1, MYL12A, and TSHZ3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter loading into synaptic vesicle activity versus SYP-AS1 in LUAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SYP-AS1 →	+0.148	+0.600	.009	.004	3	3
GBM	MYL12A →	-0.470	-0.630	.008	.002	3	3
GBM	TSHZ3 →	-0.421	-0.501	.002	<.001	3	3
GBM	CNKSR1 →	+0.503	+0.818	<.001	<.001	3	3
COAD	MYL9 →	-1.562	-0.232	<.001	<.001	3	2
COAD	CALD1 →	-0.712	-0.201	.002	.002	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098700 vs SYP-AS1 — LUAD

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