Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Across TCGA patient cohorts, RNA activity of the Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHPF, GPC4, and GPC6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane activity versus CHPF in HNSC (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CHPF →	+0.420	+0.070	.004	.008	3	8
BRCA	GPC4 →	+0.696	+0.046	<.001	<.001	3	7
GBM	GPC6 →	+0.506	+0.082	<.001	<.001	3	7
LSCC	SH3PXD2B →	+0.292	+0.077	<.001	<.001	3	6
PDAC	THBS1 →	+0.742	+0.047	.002	.005	3	6
PDAC	CNN2 →	+0.426	+0.050	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098696 vs CHPF — HNSC

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