Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Across TCGA cell cohorts, RNA activity of the Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STARD13, SMPDL3B, and GADD45GIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STARD13 grouped by Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	STARD13 →	-1.211	-1.192	.001	.003	3	5
LUNG_NSCLC_LUSC	SMPDL3B →	+2.108	+1.678	.005	<.001	3	4
LUNG_NSCLC_LUSC	GADD45GIP1 →	-0.813	-1.202	.006	.003	3	4
LUNG_NSCLC_LUSC	PURA →	-0.963	-1.564	.006	<.001	3	4
LUNG_NSCLC_LUSC	HMG20B →	-1.478	-2.043	.003	<.001	3	4
LUNG_NSCLC_LUSC	AP1M1 →	-1.296	-1.195	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STARD13 by Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane activity — LUNG_NSCLC_LUSC

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