Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Across TCGA cell cohorts, RNA activity of the Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO5A, RAP1A, and AP1AR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane activity versus MYO5A in BLOOD_Leukemia (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYO5A →	+0.858	+0.845	.004	.001	3	5
KIDNEY	RAP1A →	+0.977	+1.727	.001	.001	3	4
LIVER	AP1AR →	-0.679	-1.450	.008	<.001	3	4
STOMACH	FLCN →	-1.245	-1.188	.005	.006	3	4
KIDNEY	CPNE7 →	-4.000	-1.619	.002	.002	3	4
BLOOD_Lymphoma	TMEM150A →	-1.235	-0.969	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098696 vs MYO5A — BLOOD_Leukemia

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