Regulation of synaptic vesicle cycle

Across TCGA patient cohorts, RNA activity of the Regulation of synaptic vesicle cycle pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP5-AS1, B4GALT1, and ENHO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle cycle activity versus ARHGAP5-AS1 in UCEC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGAP5-AS1 →	+0.537	+0.675	.008	.001	3	4
UCEC	B4GALT1 →	-0.882	-0.448	<.001	.002	3	4
GBM	ENHO →	+0.919	+1.181	<.001	<.001	3	4
LUAD	PIK3R3 →	+0.540	+0.455	.004	.007	3	3
BRCA	MYC →	-0.693	-0.546	.007	.006	3	3
LUAD	CFAP74 →	+0.411	+0.496	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098693 vs ARHGAP5-AS1 — UCEC

Explore this scatter interactively →