G protein-coupled serotonin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the G protein-coupled serotonin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPFIBP1, SRPX2, and SF3B1_S251, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled serotonin receptor signaling pathway activity versus PPFIBP1 in LSCC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPFIBP1 →	+0.320	+0.043	.009	.001	3	5
PDAC	SRPX2 →	+0.331	+0.018	.004	.007	3	5
LUAD	SF3B1_S251 →	-0.532	-0.048	<.001	<.001	3	4
OV	CDKAL1 →	-0.267	-0.036	.007	.001	3	4
BRCA	SVIL →	+0.344	+0.037	<.001	<.001	3	4
BRCA	FSTL1 →	+0.561	+0.035	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098664 vs PPFIBP1 — LSCC

Explore this scatter interactively →