G protein-coupled serotonin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the G protein-coupled serotonin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGTLC2, CHCHD4P4, and LSP1P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled serotonin receptor signaling pathway activity versus GGTLC2 in COAD (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GGTLC2 →	+0.034	+0.232	.003	<.001	3	3
LSCC	CHCHD4P4 →	+0.762	+0.321	<.001	<.001	3	3
PDAC	LSP1P2 →	+0.798	+0.244	<.001	.001	3	3
GBM	SBDS →	+0.410	+0.407	.005	.006	3	3
GBM	KIAA0513 →	+0.649	+0.544	.003	.005	3	3
GBM	FABP1 →	+0.119	+0.358	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098664 vs GGTLC2 — COAD

Explore this scatter interactively →