G protein-coupled serotonin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the G protein-coupled serotonin receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HRH3, HTR1A, and ATP6V1B2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HRH3 grouped by G protein-coupled serotonin receptor signaling pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HRH3 →	-0.457	-1.175	.002	<.001	3	12
KIDNEY	HTR1A →	-0.216	-1.171	<.001	<.001	3	7
LARGE_INTESTINE	ATP6V1B2 →	+0.368	+0.689	.003	.003	3	6
OVARY	SLC16A6 →	-0.281	-0.797	.003	.005	3	5
LUNG_NSCLC_LUAD	GPR50 →	-0.158	-0.538	.008	.002	3	5
LUNG_SCLC	ARG1 →	-0.175	-1.247	.007	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HRH3 by G protein-coupled serotonin receptor signaling pathway activity — STOMACH

Explore this box plot interactively →