G protein-coupled serotonin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the G protein-coupled serotonin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAI1, MED25, and RANBP10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled serotonin receptor signaling pathway activity versus GNAI1 in PANCREAS (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GNAI1 →	+2.201	+1.491	.003	<.001	3	5
LUNG_NSCLC_LUAD	MED25 →	+0.439	+0.621	.002	.004	3	4
LUNG_NSCLC_LUAD	RANBP10 →	+0.662	+0.804	.003	.005	3	4
LUNG_NSCLC_LUAD	GNAQ →	+0.949	+1.074	<.001	<.001	3	4
LUNG_NSCLC_LUAD	MARK4 →	+1.108	+1.131	<.001	<.001	3	4
BREAST	GNE →	+1.619	+1.094	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098664 vs GNAI1 — PANCREAS

Explore this scatter interactively →