Detection of external biotic stimulus

Across TCGA patient cohorts, RNA activity of the Detection of external biotic stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HLA-A, SKAP2, and HCK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of external biotic stimulus activity versus HLA-A in OV (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HLA-A →	+1.395	+0.375	<.001	<.001	3	8
OV	SKAP2 →	+0.416	+0.264	<.001	.002	3	7
GBM	HCK →	+0.558	+0.284	.002	.001	3	7
LSCC	HLA-A_S352 →	+2.199	+0.440	<.001	<.001	3	7
LSCC	HLA-A_S356 →	+2.175	+0.438	<.001	<.001	3	7
HNSC	HLA-A_S359 →	+2.073	+0.325	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098581 vs HLA-A — OV

Explore this scatter interactively →