Detection of external biotic stimulus

Across TCGA cell cohorts, RNA activity of the Detection of external biotic stimulus pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SALL4, CREB3L2, and OR13A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SALL4 grouped by Detection of external biotic stimulus-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SALL4 →	-0.956	-1.004	<.001	.001	3	4
BLOOD_Lymphoma	CREB3L2 →	-3.260	-2.043	.008	.003	2	4
BLOOD_Lymphoma	OR13A1 →	+3.155	+2.079	<.001	<.001	3	3
BREAST	H2BC9 →	-1.153	-0.922	<.001	.002	2	4
SOFT_TISSUE	SLC35E4 →	-1.375	-1.364	.001	.001	3	3
SOFT_TISSUE	MAPKAPK3 →	-1.460	-1.043	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SALL4 by Detection of external biotic stimulus activity — CNS

Explore this box plot interactively →