Detection of other organism

Across TCGA patient cohorts, RNA activity of the Detection of other organism pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FNBP1, RCSD1, and SAMHD1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of other organism activity versus FNBP1 in LSCC (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FNBP1 →	+0.401	+0.062	<.001	<.001	3	9
GBM	RCSD1 →	+0.648	+0.119	<.001	<.001	3	8
UCEC	SAMHD1 →	+0.505	+0.046	.002	.005	3	8
LSCC	TRIM22 →	+0.462	+0.066	<.001	<.001	3	8
GBM	CAPZB →	+0.206	+0.102	<.001	<.001	3	8
COAD	CTSL →	+0.419	+0.026	.001	.005	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098543 vs FNBP1 — LSCC

Explore this scatter interactively →