Detection of other organism

Across TCGA patient cohorts, RNA activity of the Detection of other organism pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LCP2, GBP4, and HLA-F, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of other organism activity versus LCP2 in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LCP2 →	+0.605	+0.216	.005	.007	2	7
HNSC	GBP4 →	+0.835	+0.168	.004	<.001	3	6
BRCA	HLA-F →	+1.192	+0.263	<.001	<.001	3	6
PDAC	CYTH4 →	+0.558	+0.211	<.001	<.001	3	5
LSCC	MEFV →	+0.525	+0.325	<.001	<.001	3	5
LSCC	LILRB1 →	+0.695	+0.427	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098543 vs LCP2 — GBM

Explore this scatter interactively →