Detection of other organism

Across TCGA cell cohorts, RNA activity of the Detection of other organism pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARNTL2, CCP110, and PNMA5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARNTL2 grouped by Detection of other organism-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ARNTL2 →	-1.527	-1.204	.001	.001	3	4
PANCREAS	CCP110 →	+0.931	+1.320	.002	<.001	3	3
PANCREAS	PNMA5 →	+0.064	+1.379	.004	<.001	3	3
OVARY	GDF6 →	+0.777	+1.123	.005	.001	2	4
BLOOD_Myeloma	SLC35E4 →	-1.083	-1.053	.002	.009	2	4
BLOOD_Myeloma	ESR2 →	-1.205	-1.104	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARNTL2 by Detection of other organism activity — KIDNEY

Explore this box plot interactively →