Detection of other organism

Across TCGA cell cohorts, RNA activity of the Detection of other organism pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD15, NPW, and NFATC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of other organism activity versus ABHD15 in SKIN (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ABHD15 →	-1.061	-0.432	.001	.004	3	3
SKIN	NPW →	-0.302	-0.441	.004	.002	3	3
LUNG_NSCLC_LUAD	NFATC2 →	-1.219	-0.378	.001	.002	3	3
BLOOD_Myeloma	CYTIP →	+1.566	+0.353	.007	<.001	3	3
BLOOD_Myeloma	DUSP1 →	+2.096	+0.271	.003	.007	3	3
BLOOD_Lymphoma	JAK3 →	+3.151	+0.523	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098543 vs ABHD15 — SKIN

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