Centriole assembly

Across TCGA cell cohorts, RNA activity of the Centriole assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDM12, ARHGEF6, and ATAD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRDM12 grouped by Centriole assembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRDM12 →	+0.217	+0.383	<.001	.001	3	6
OESOPHAGUS	ARHGEF6 →	-0.170	-0.428	.001	.001	3	5
BONE	ATAD1 →	+0.226	+0.491	<.001	.001	3	4
LUNG_NSCLC_LUAD	BTN1A1 →	+0.192	+0.485	<.001	.001	3	4
LIVER	TIGD7 →	+0.108	+0.240	.002	.006	3	4
LUNG_SCLC	CDH23 →	+0.275	+0.315	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRDM12 by Centriole assembly activity — OESOPHAGUS

Explore this box plot interactively →