Centriole assembly

Across TCGA cell cohorts, RNA activity of the Centriole assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BOLA2, SYN3, and SIRPA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BOLA2 grouped by Centriole assembly-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BOLA2 →	-0.982	-0.532	.003	.002	3	3
BLOOD_Lymphoma	SYN3 →	+0.146	+0.564	.007	.008	3	3
LIVER	SIRPA →	-1.444	-0.948	.001	.008	3	3
LUNG_SCLC	GPX8 →	-4.021	-0.411	.001	<.001	3	3
LUNG_SCLC	DCAF12 →	+1.027	+0.355	.004	.003	3	3
CNS	CERCAM →	-1.080	-0.806	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BOLA2 by Centriole assembly activity — BLOOD_Lymphoma

Explore this box plot interactively →