Centriole assembly

Across TCGA cell cohorts, RNA activity of the Centriole assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP135, ATAD5, and CEP152, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centriole assembly activity versus CEP135 in LARGE_INTESTINE (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CEP135 →	+1.124	+0.097	<.001	<.001	3	20
URINARY_TRACT	ATAD5 →	+1.317	+0.101	<.001	.002	3	20
LUNG_NSCLC_LUSC	CEP152 →	+1.454	+0.087	.004	.005	3	20
BONE	KIF14 →	+1.297	+0.120	.005	.004	3	20
URINARY_TRACT	CIT →	+1.560	+0.111	<.001	<.001	3	20
BONE	PLK4 →	+1.388	+0.128	.006	.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098534 vs CEP135 — LARGE_INTESTINE

Explore this scatter interactively →