De novo centriole assembly

Across TCGA patient cohorts, RNA activity of the De novo centriole assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM5, OIP5, and CDCA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, De novo centriole assembly activity versus MCM5 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MCM5 →	+0.636	+0.126	.001	<.001	3	4
BRCA	OIP5 →	+0.526	+0.100	<.001	<.001	3	4
BRCA	CDCA3 →	+1.027	+0.162	<.001	<.001	3	4
BRCA	E2F3 →	+0.761	+0.162	<.001	<.001	3	4
LUAD	CSMD2 →	+0.350	+0.155	.002	<.001	3	4
BRCA	TROAP →	+0.990	+0.191	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097742 vs MCM5 — BRCA

Explore this scatter interactively →