De novo centriole assembly

Across TCGA cell cohorts, RNA activity of the De novo centriole assembly pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THAP9, GPRIN3, and KIF18A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, THAP9 grouped by De novo centriole assembly-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	THAP9 →	+1.431	+1.710	.008	<.001	3	5
LUNG_SCLC	GPRIN3 →	+2.977	+1.316	<.001	.009	3	4
LUNG_NSCLC_LUSC	KIF18A →	-0.932	-1.577	.009	.001	3	3
UPPER_AERODIGESTIVE_TRACT	C9orf85 →	+0.844	+1.482	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CES4A →	+2.612	+2.168	.001	<.001	3	3
CNS	CAMLG →	+1.004	+1.710	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THAP9 by De novo centriole assembly activity — CNS

Explore this box plot interactively →