Sperm motility

Across TCGA patient cohorts, RNA activity of the Sperm motility pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSTYK, FAM241A, and IRAG1-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm motility activity versus DSTYK in GBM (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DSTYK →	+0.265	+0.234	<.001	.001	3	3
CCRCC	FAM241A →	+0.463	+0.245	<.001	.004	3	3
CCRCC	IRAG1-AS1 →	+0.674	+0.268	<.001	<.001	3	3
CCRCC	INKA1 →	+0.818	+0.243	<.001	<.001	3	3
OV	RPSAP18 →	+0.676	+0.413	.004	.008	3	3
BRCA	KIAA0040 →	+0.789	+0.643	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097722 vs DSTYK — GBM

Explore this scatter interactively →