Calcineurin-mediated signaling

Across TCGA patient cohorts, RNA activity of the Calcineurin-mediated signaling pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADPRH, NFATC2, and SH3KBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcineurin-mediated signaling activity versus ADPRH in HNSC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ADPRH →	+0.317	+0.038	.001	.003	3	8
GBM	NFATC2 →	+0.372	+0.035	<.001	<.001	3	8
LSCC	SH3KBP1 →	+0.395	+0.037	.001	.004	3	7
GBM	DOK2 →	+0.762	+0.046	<.001	.001	3	7
BRCA	FNBP1 →	+0.285	+0.035	.002	<.001	3	7
BRCA	CD3E →	+0.502	+0.034	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097720 vs ADPRH — HNSC

Explore this scatter interactively →