Calcineurin-mediated signaling

Across TCGA patient cohorts, RNA activity of the Calcineurin-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHISAL2A, LINC01857, and CCDC80, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcineurin-mediated signaling activity versus SHISAL2A in LSCC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SHISAL2A →	+0.596	+0.956	<.001	<.001	3	5
HNSC	LINC01857 →	+0.599	+0.639	.008	.003	2	6
HNSC	CCDC80 →	+0.676	+0.669	.006	.002	3	5
PDAC	MS4A6A →	+0.393	+0.231	.001	.003	3	5
UCEC	CD247 →	+0.837	+0.451	<.001	.009	3	5
LSCC	NT5C3AP2 →	+0.811	+0.911	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097720 vs SHISAL2A — LSCC

Explore this scatter interactively →