Calcineurin-mediated signaling

Across TCGA cell cohorts, RNA activity of the Calcineurin-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL2B, FAM199X, and RAB5A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, METTL2B grouped by Calcineurin-mediated signaling-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	METTL2B →	+0.386	+0.646	.002	<.001	3	4
BLOOD_Myeloma	FAM199X →	+0.789	+1.407	.004	<.001	2	5
BLOOD_Myeloma	RAB5A →	+0.693	+1.830	.001	<.001	3	4
BLOOD_Myeloma	COL5A2 →	+0.480	+1.773	.009	<.001	3	4
BLOOD_Myeloma	PCM1 →	+1.106	+1.247	<.001	.003	3	4
BLOOD_Myeloma	USP40 →	+1.025	+1.353	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

METTL2B by Calcineurin-mediated signaling activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →