Cell surface receptor signaling pathway via STAT

Across TCGA cell cohorts, RNA activity of the Cell surface receptor signaling pathway via STAT pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT1, STAT3, and NPEPPS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell surface receptor signaling pathway via STAT activity versus STAT1 in BLOOD_Lymphoma (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	STAT1 →	+2.306	+1.057	<.001	<.001	3	6
BLOOD_Lymphoma	STAT3 →	+1.703	+1.036	<.001	<.001	3	5
BLOOD_Lymphoma	NPEPPS →	+0.923	+1.413	<.001	<.001	3	5
LUNG_SCLC	CPOX →	+0.520	+0.512	.002	.005	3	4
LIVER	SRSF2 →	+0.722	+0.315	.008	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NAP1L4 →	+0.754	+0.502	.007	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097696 vs STAT1 — BLOOD_Lymphoma

Explore this scatter interactively →