Calcitonin family receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Calcitonin family receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNM, COL4A2, and ERG_S81, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcitonin family receptor signaling pathway activity versus SYNM in HNSC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SYNM →	+0.861	+0.099	<.001	<.001	3	9
COAD	COL4A2 →	+0.545	+0.087	<.001	<.001	3	9
CCRCC	ERG_S81 →	+0.800	+0.135	<.001	<.001	3	9
CCRCC	MMRN2 →	+0.537	+0.135	<.001	<.001	3	9
HNSC	SYNPO2_T755 →	+0.633	+0.078	<.001	.005	3	9
COAD	TNS1 →	+0.500	+0.086	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097646 vs SYNM — HNSC

Explore this scatter interactively →