Granulocyte migration

Across TCGA cell cohorts, RNA activity of the Granulocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCTD1, SERAC1, and P2RY4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCTD1 grouped by Granulocyte migration-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCTD1 →	+1.184	+1.019	.005	.006	3	4
LIVER	SERAC1 →	-0.701	-1.215	.002	.004	3	4
URINARY_TRACT	P2RY4 →	-0.195	-1.400	.002	.004	3	4
CNS	SUB1 →	-0.489	-0.708	.009	.002	3	3
CNS	TBC1D15 →	+0.378	+0.812	.008	.005	3	3
CNS	ECHDC3 →	+1.360	+0.827	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCTD1 by Granulocyte migration activity — BLOOD_Leukemia

Explore this box plot interactively →