Sialylation

Across TCGA patient cohorts, RNA activity of the Sialylation pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST3GAL4, ST6GAL1, and ST3GAL2, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sialylation activity versus ST3GAL4 in KICH (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	ST3GAL4 →	+1.581	+0.058	.002	.001	3	19
KICH	ST6GAL1 →	+2.005	+0.098	<.001	<.001	3	19
ESCA	ST3GAL2 →	+0.759	+0.075	<.001	<.001	3	18
ACC	PPP1R16B →	+1.012	+0.063	<.001	<.001	2	18
SARC	DENND3 →	+0.557	+0.049	<.001	<.001	3	17
SARC	CFP →	+0.732	+0.046	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097503 vs ST3GAL4 — KICH

Explore this scatter interactively →