Sialylation

Across TCGA pan-cancer cohorts, RNA activity of the Sialylation pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Sialylation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and LGG, show the opposite pattern, with higher activity associated with better survival.

HNSC, KIRC, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.729	0.523	<.001	86	view →
KIRC	DFS	Median	All	0.834	0.906	<.001	81	view →
THCA	OS	Median	II,III,IV	0.944	0.999	<.001	28	view →
LGG	DFS	Median	All	0.879	0.786	<.001	27	view →
LIHC	OS	Quartile	III,IV	0.161	0.732	<.001	26	view →
SCLC	DFS	Tertile	All	0.494	0.824	.001	22	view →
CESC	OS	Tertile	IV	0.708	0.300	.021	12	view →
OV	DFS	Quartile	IV	0.287	0.622	.004	10	view →
READ	DFS	Quartile	IV	0.782	0.304	.033	9	view →
LUSC	DFS	Quartile	All	0.273	0.452	.018	8	view →
UVM	OS	Tertile	III,IV	0.419	0.867	.036	8	view →
KICH	DFS	Quartile	III,IV	1.000	0.059	.017	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0097503–HNSC (DFS)

Open the HNSC breakdown →