Sialylation

Across TCGA patient cohorts, RNA activity of the Sialylation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST6GAL1, MEI1, and POU2AF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sialylation activity versus ST6GAL1 in BRCA (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ST6GAL1 →	+1.485	+0.286	<.001	<.001	3	6
HNSC	MEI1 →	+0.642	+0.668	<.001	<.001	3	5
BRCA	POU2AF1 →	+1.077	+0.189	.009	.002	3	5
HNSC	LAX1 →	+0.849	+0.556	.001	<.001	3	5
BRCA	FCRL5 →	+1.191	+0.230	.003	<.001	3	5
HNSC	IGKC →	+2.316	+0.542	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097503 vs ST6GAL1 — BRCA

Explore this scatter interactively →