Sialylation

Across TCGA patient cohorts, RNA activity of the Sialylation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ST6GAL1, SEC24A, and DERL3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sialylation activity versus ST6GAL1 in UCEC (Pearson r = 0.81).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ST6GAL1 →	+0.976	+0.438	<.001	.001	3	8
LSCC	SEC24A →	+0.394	+0.655	<.001	<.001	3	5
BRCA	DERL3 →	+0.924	+0.217	.001	.001	3	4
HNSC	SPCS1 →	+0.483	+0.604	<.001	<.001	3	3
CCRCC	STT3B_S498 →	+0.686	+0.572	.001	.007	3	3
HNSC	CYP20A1 →	+0.343	+0.780	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097503 vs ST6GAL1 — UCEC

Explore this scatter interactively →