Regulation of vesicle size

Across TCGA cell cohorts, RNA activity of the Regulation of vesicle size pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D2, MAML2, and PICALM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vesicle size activity versus TBC1D2 in CNS (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TBC1D2 →	+1.423	+0.786	.001	.002	3	6
OESOPHAGUS	MAML2 →	+1.541	+0.942	<.001	.009	3	5
KIDNEY	PICALM →	+1.169	+1.158	.002	.001	3	5
LARGE_INTESTINE	FOSL2 →	+1.359	+0.906	.002	.004	2	6
CNS	NDST1 →	+0.861	+0.873	<.001	<.001	3	5
SOFT_TISSUE	SLC22A4 →	+2.164	+1.689	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097494 vs TBC1D2 — CNS

Explore this scatter interactively →