Sympathetic neuron projection extension

Across TCGA patient cohorts, RNA activity of the Sympathetic neuron projection extension pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NRP2, MMP14, and SH3PXD2B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sympathetic neuron projection extension activity versus NRP2 in OV (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NRP2 →	+0.746	+0.092	<.001	<.001	3	9
GBM	MMP14 →	+0.572	+0.078	.001	.002	3	8
UCEC	SH3PXD2B →	+0.389	+0.137	<.001	<.001	3	7
LSCC	TGFBI →	+0.724	+0.102	<.001	<.001	3	7
COAD	ACTN1 →	+0.681	+0.061	<.001	<.001	3	7
COAD	TUBB6 →	+0.490	+0.062	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097490 vs NRP2 — OV

Explore this scatter interactively →