Sympathetic neuron projection extension

Across TCGA pan-cancer cohorts, RNA activity of the Sympathetic neuron projection extension pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Sympathetic neuron projection extension pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and PCPG, show the opposite pattern, with higher activity associated with better survival.

LGG, STAD, and TGCT are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Tertile	All	0.831	0.940	<.001	36	view →
STAD	DFS	Median	IV	0.158	0.565	.012	20	view →
TGCT	DFS	Tertile	All	0.534	0.832	.004	18	view →
ACC	DFS	Quartile	All	0.301	0.621	.005	16	view →
MESO	DFS	Quartile	III,IV	0.554	0.309	<.001	13	view →
SCLC	OS	Median	II,III,IV	0.182	0.492	.012	13	view →
PCPG	DFS	Tertile	All	1.000	0.831	.006	11	view →
READ	DFS	Median	IV	0.820	0.383	.006	11	view →
ESCA	DFS	Tertile	III,IV	0.474	0.240	.023	9	view →
THYM	DFS	Median	All	0.929	0.814	.021	7	view →
GBM	OS	Median	All	0.348	0.471	.015	6	view →
DLBC	DFS	Tertile	II,III,IV	0.422	1.000	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0097490–LGG (OS)

Open the LGG breakdown →