Sympathetic neuron projection extension

Across TCGA cell cohorts, RNA activity of the Sympathetic neuron projection extension pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDRGK1, ZNF280C, and SOX7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDRGK1 grouped by Sympathetic neuron projection extension-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DDRGK1 →	-1.210	-1.274	.004	.007	3	5
SOFT_TISSUE	ZNF280C →	+0.701	+1.531	.003	<.001	3	5
LUNG_SCLC	SOX7 →	+1.010	+1.008	.007	.002	3	5
BONE	ZC3H12B →	+0.718	+0.969	.007	.005	3	4
KIDNEY	ADAM11 →	+0.773	+1.202	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	NECAB3 →	-1.660	-1.560	.007	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDRGK1 by Sympathetic neuron projection extension activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →