Sympathetic neuron projection extension

Across TCGA cell cohorts, RNA activity of the Sympathetic neuron projection extension pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX21, CKS1B, and POLA1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sympathetic neuron projection extension activity versus DDX21 in SKIN (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DDX21 →	-1.559	-2.125	.001	.002	2	1
SKIN	CKS1B →	-1.196	-2.155	.003	.001	2	1
SKIN	POLA1 →	-1.040	-2.023	.007	.004	1	1
SKIN	MCM4 →	-1.220	-2.155	<.001	.001	1	1
SKIN	MS4A3 →	-0.370	-2.035	.005	.004	1	1
SKIN	DPEP2 →	-0.075	-2.039	.004	<.001	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097490 vs DDX21 — SKIN

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