Dendrite extension

Across TCGA patient cohorts, RNA activity of the Dendrite extension pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AUTS2, LINC02210, and APBA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendrite extension activity versus AUTS2 in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AUTS2 →	+0.814	+0.497	<.001	.002	3	5
GBM	LINC02210 →	+0.755	+0.899	<.001	<.001	3	5
LUAD	APBA1 →	+0.569	+0.261	.001	.001	3	4
LUAD	SUSD4 →	+0.908	+0.201	.001	.004	3	4
LUAD	SYT2 →	+0.894	+0.249	<.001	<.001	3	4
HNSC	PDIK1L →	+0.425	+0.473	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097484 vs AUTS2 — HNSC

Explore this scatter interactively →