Synaptic vesicle localization

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle localization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATL1_S23, ZC3H18_T162, and ATP6V0D1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle localization activity versus ATL1_S23 in GBM (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATL1_S23 →	+0.686	+0.068	<.001	<.001	3	5
CCRCC	ZC3H18_T162 →	-1.296	-0.039	.001	.008	3	5
GBM	ATP6V0D1 →	+0.640	+0.061	<.001	<.001	3	4
PDAC	TANC2 →	+0.365	+0.033	<.001	<.001	3	4
HNSC	DTX3L_S202 →	+0.585	+0.041	.003	.004	3	4
COAD	PEX14_S44 →	+0.632	+0.026	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097479 vs ATL1_S23 — GBM

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