Synaptic vesicle localization

Across TCGA pan-cancer cohorts, RNA activity of the Synaptic vesicle localization pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 54 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Synaptic vesicle localization pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and PAAD, show the opposite pattern, with higher activity associated with better survival.

KIRP, PAAD, and DLBC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	1.000	0.489	.001	35	view →
PAAD	DFS	Median	All	0.440	0.205	.004	24	view →
DLBC	DFS	Tertile	All	0.655	1.000	.006	21	view →
LGG	OS	Tertile	All	0.971	0.842	<.001	18	view →
THCA	OS	Tertile	All	0.945	0.986	.010	17	view →
LUAD	OS	Quartile	All	0.879	0.730	.012	12	view →
KICH	OS	Quartile	II,III,IV	0.920	1.000	.033	11	view →
CHOL	OS	Quartile	All	0.855	0.514	.046	9	view →
LIHC	OS	Quartile	All	0.772	0.363	.011	9	view →
SKCM	DFS	Median	All	0.677	0.771	.009	7	view →
UVM	DFS	Quartile	III,IV	0.385	0.918	.020	6	view →
SCLC	OS	Tertile	II,III,IV	1.000	0.427	.016	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0097479–KIRP (DFS)

Open the KIRP breakdown →