Synaptic vesicle localization

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle localization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMRN1, CLEC10A, and ANKRD55, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle localization activity versus MMRN1 in LSCC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MMRN1 →	+0.971	+0.256	<.001	<.001	3	4
LSCC	CLEC10A →	+0.835	+0.282	.003	<.001	3	4
LSCC	ANKRD55 →	+0.360	+0.234	.006	.001	3	4
LSCC	PTGDS →	+0.624	+0.168	<.001	.006	3	3
PDAC	OPRD1 →	+0.154	+0.975	.002	<.001	3	3
LSCC	NAPSB →	+0.712	+0.195	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097479 vs MMRN1 — LSCC

Explore this scatter interactively →