Synaptic vesicle localization

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle localization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R18, RAE1, and ASB6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R18 grouped by Synaptic vesicle localization-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PPP1R18 →	-1.480	-1.112	<.001	.005	3	6
OESOPHAGUS	RAE1 →	-0.794	-1.332	.005	<.001	3	4
OESOPHAGUS	ASB6 →	-0.641	-1.218	.001	.004	3	4
OESOPHAGUS	LMNB2 →	-0.746	-1.328	.002	<.001	3	4
LARGE_INTESTINE	STARD3NL →	-0.896	-1.007	<.001	.003	3	4
KIDNEY	ACD →	-1.065	-1.329	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R18 by Synaptic vesicle localization activity — OVARY

Explore this box plot interactively →