Synaptic vesicle localization

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle localization pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPO, ELP1, and TMEM117, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LPO grouped by Synaptic vesicle localization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LPO →	-0.235	-1.246	.008	.006	3	4
OESOPHAGUS	ELP1 →	-0.171	-0.241	.004	.007	3	4
OVARY	TMEM117 →	-0.322	-0.165	<.001	.001	3	3
KIDNEY	GJB4 →	+0.243	+0.324	.006	<.001	3	3
KIDNEY	DSG2 →	-0.286	-0.324	<.001	<.001	3	3
BLOOD_Lymphoma	FAM178B →	+0.446	+1.762	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LPO by Synaptic vesicle localization activity — BLOOD_Leukemia

Explore this box plot interactively →