Synaptic vesicle localization

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle localization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK19, HNRNPA1, and RPL34, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle localization activity versus STK19 in BLOOD_Myeloma (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	STK19 →	+1.199	+1.476	.004	.001	3	6
PANCREAS	HNRNPA1 →	-0.891	-0.887	<.001	.009	3	6
CNS	RPL34 →	-0.462	-0.187	.008	.004	3	5
CNS	QSOX1 →	+1.484	+0.246	.001	.001	3	5
BREAST	IGFBP2 →	-2.720	-0.726	.002	.002	3	5
BREAST	LTBP2 →	+1.179	+0.561	.007	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097479 vs STK19 — BLOOD_Myeloma

Explore this scatter interactively →