Liver regeneration

Across TCGA cell cohorts, RNA activity of the Liver regeneration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCAMP3, SLC35C2, and TFAP2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Liver regeneration activity versus SCAMP3 in LUNG_NSCLC_LUSC (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SCAMP3 →	-0.630	-0.328	.002	.001	3	5
UPPER_AERODIGESTIVE_TRACT	SLC35C2 →	-0.775	-0.196	.009	.009	3	4
URINARY_TRACT	TFAP2C →	-3.327	-0.249	.004	.004	3	4
LUNG_NSCLC_LUSC	NME3 →	-1.305	-0.460	.001	<.001	3	4
LUNG_NSCLC_LUSC	AHCYL2 →	-1.152	-0.328	.001	.001	3	4
BONE	AMBRA1 →	-1.072	-0.159	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097421 vs SCAMP3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →