Hypoxia-inducible factor-1alpha signaling pathway

Across TCGA patient cohorts, RNA activity of the Hypoxia-inducible factor-1alpha signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAP1L4, PDK1, and SERPINE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypoxia-inducible factor-1alpha signaling pathway activity versus NAP1L4 in BRCA (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NAP1L4 →	-0.179	-0.043	.001	.001	3	5
GBM	PDK1 →	+0.501	+0.073	<.001	.002	3	5
GBM	SERPINE1 →	+0.870	+0.078	.001	.001	3	5
GBM	SKP1 →	-0.249	-0.072	.006	.009	1	6
CCRCC	CNTLN_S22 →	+0.471	+0.078	.003	<.001	3	4
PDAC	DYNLL1 →	-0.142	-0.032	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097411 vs NAP1L4 — BRCA

Explore this scatter interactively →