Hypoxia-inducible factor-1alpha signaling pathway

Across TCGA cell cohorts, RNA activity of the Hypoxia-inducible factor-1alpha signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC23A2, OCEL1, and HLA-E, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hypoxia-inducible factor-1alpha signaling pathway activity versus SLC23A2 in BLOOD_Leukemia (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC23A2 →	+0.657	+1.525	.007	.004	3	1
BLOOD_Leukemia	OCEL1 →	+1.337	+1.525	.002	.004	3	1
BLOOD_Leukemia	HLA-E →	+2.026	+1.742	.008	<.001	3	1
BLOOD_Leukemia	ZNF717 →	-2.920	-1.774	<.001	<.001	3	1
BLOOD_Leukemia	ZNF492 →	-1.383	-1.742	<.001	<.001	3	1
BLOOD_Leukemia	CLEC12B →	+4.046	+1.656	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097411 vs SLC23A2 — BLOOD_Leukemia

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