Synaptic vesicle lumen acidification

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle lumen acidification pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP2S1, CCDC82, and CYP7B1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle lumen acidification activity versus AP2S1 in HNSC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AP2S1 →	+0.527	+0.088	.001	<.001	3	5
BRCA	CCDC82 →	-0.545	-0.118	<.001	.007	3	4
BRCA	CYP7B1 →	-0.881	-0.214	.001	.002	3	4
HNSC	TMEM220 →	-0.734	-0.129	<.001	<.001	3	4
HNSC	TTTY10 →	-0.464	-0.086	<.001	.003	3	4
HNSC	ERVK9-11 →	-0.537	-0.068	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097401 vs AP2S1 — HNSC

Explore this scatter interactively →