Q-omics provides the consensus-scored TTTY10 profile across patient tissues and cancer cell-line models. TTTY10 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, TTTY10 is differentially expressed in 5, with the highest sampling consensus in KIRP. Additionally, TTTY10 RNA expression shows 9,892 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight UVM, KIRP, and HNSC as cancer lineages where TTTY10 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TTTY10 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TTTY10 survival associations across molecular data types. TTTY10 RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TTTY10 RNA expression–survival associations across cancer types. High TTTY10 expression shows unfavorable associations in KIRP and LUAD, but favorable associations in UVM, MESO, HNSC and THYM. The UVM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for TTTY10 RNA expression.
This table summarizes TTTY10 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in KIRP for RNA.
This table ranks reproducible tumor–normal expression differences for TTTY10. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TTTY10 shows lower tumor expression in KIRP, KICH, LUSC, KIRC and STAD. The KIRP box plot shows higher TTTY10 RNA expression in normal versus tumor tissue (log2 FC = −0.302, t-test p < 0.001).
This table shows molecular features associated with TTTY10 in patient tissues and cancer cell lines. In patient samples, TTTY10 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set.
