Autophagosome maturation

Across TCGA cell cohorts, RNA activity of the Autophagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP4, SHARPIN, and PIAS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRP4 grouped by Autophagosome maturation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LRP4 →	-2.786	-0.343	<.001	.001	3	6
KIDNEY	SHARPIN →	+0.521	+0.280	.006	.006	3	6
URINARY_TRACT	PIAS2 →	-1.008	-0.176	<.001	.001	3	5
PANCREAS	IL1RN →	+2.371	+0.182	<.001	.003	3	5
OVARY	PBX3 →	-1.641	-0.292	.009	<.001	3	5
PANCREAS	CHN1 →	-1.739	-0.230	.003	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRP4 by Autophagosome maturation activity — LUNG_SCLC

Explore this box plot interactively →