Neutrophil clearance

Across TCGA patient cohorts, RNA activity of the Neutrophil clearance pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADPRH, ANKRD44, and ABI3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil clearance activity versus ADPRH in HNSC (Pearson r = -0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ADPRH →	+0.386	+0.072	<.001	.001	3	9
UCEC	ANKRD44 →	+0.362	+0.056	.001	.002	3	9
GBM	ABI3 →	+0.518	+0.094	<.001	<.001	3	9
LUAD	INPP5D →	+0.412	+0.067	<.001	.001	3	9
LUAD	ARHGEF6_S684 →	+0.836	+0.076	<.001	<.001	3	9
OV	AKAP12_S612 →	+0.922	+0.036	.002	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097350 vs ADPRH — HNSC

Explore this scatter interactively →